Article Title:

Frequency and Predictors of Hypoglycaemia in Type 1 and Insulin-treated Type 2 diabetes: a population based study

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Diabet Med. 2005 Jun;22(6):749-55


Donnelly LA, Morris AD, Frier BM, Ellis JD, Donnan PT, Durrant R, Band MM, Geekie G, Leese GP; DATRS/MEMO Collaboration


Medicines Monitoring Unit, Ninewells Hospital and Medical School, Dundee, UK.


To ascertain the frequency and identify predictors of self-reported hypoglycaemia in Type 1 and insulin-treated Type 2 Diabetes.


A random sample of 267 people with insulin-treated diabetes were recruited from a population-based diabetes register in Tayside, Scotland. Each subject prospectiveyl recorded the number of mild and sever hypoglycaemic episodes experienced over a 1 month period. Ordinal logistic regression was performed to identify potential predictors of hypoglycaemia.


Five Hundred and seventy-two hypoglycaemic events were reported by 155 patients. The participants with Type 1 diabetes had a total of 336 hypoglycaemic events with a rate of 42.89 events per patient per year. Of there nine were severe hypoglycaemic events, with a rate of 1.15 events per patient per year. Participants with insulin-treated Type 2 diabetes experienced a total of 236 hypoglycaemic events with a rate of 16.37 events per patient per year. Of these, five were severe hypoglycaemic ebents, which would be equivelant to 0.35 events per patient per year. Predictors of hypoglycaemia in type 1 diabetes were a history of previous hypoglycaemia (P = 0.006) and co-prescribing of any oral drug (P = 0.048). In Patients with insulin-treated Type 2 diabetes, a history of previous hypoglycaemia (P < 0.0001) and duration of insulin treatment (P = 0.014) were significant predictors.


The incidence of self-reported sever hypoglycaemia in insulin-treated Type 2 diabetes is lower than in Type 1 diabetes but does not occur more often than previously reported and with sufficient frequency to cause significant morbidity. Duration of insulin treatment is a key predictor of hypoglyceamia in insulin treated Type 2 diabetes

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